Title :
Metal nanoshells: a novel substrate for immunoassays
Author :
Hirsch, L.R. ; West, J.L. ; Jackson, J.B. ; Moran, C.E. ; Halas, N.J.
Author_Institution :
Dept. of Bioeng., Rice Univ., Houston, TX, USA
Abstract :
Summary form only given. Metal nanoshells are a novel class of nanoparticles with unique optical properties, including a tunable optical absorption and substantial enhancement of Raman scattering. Conventional roughened metal SERS substrates demonstrate optimal SERS enhancement at a single wavelength due to their fixed plasmon resonance. Metal nanoshells, however, possess a tunable plasmon resonance-permitting SERS in the Near-IR "water window" of 800-1300 nm, where deep optical penetration into biological samples should permit retrieval of Raman signals across tissue boundaries. This study examines the use of metal nanoshells as a substrate for the rapid, solution-based optical detection of analytes in complex biological solutions such as whole blood, using near-IR surface-enhanced Raman scattering.
Keywords :
biochemistry; biological techniques; blood; infrared spectra; light absorption; nanostructured materials; plasmons; surface enhanced Raman scattering; 800 to 1300 nm; Raman scattering enhancement; Raman signals retrieval; analytes; biological samples; complex biological solutions; conventional roughened metal SERS substrates; deep optical penetration; immunoassay substrate; near-IR surface-enhanced Raman scattering; near-IR water window; optical properties; rapid solution-based optical detection; tissue boundaries; tunable optical absorption; whole blood; Absorption; Biological tissues; Biomedical optical imaging; Immune system; Nanobioscience; Nanoparticles; Optical scattering; Plasmons; Raman scattering; Resonance;
Conference_Titel :
Lasers and Electro-Optics, 2001. CLEO '01. Technical Digest. Summaries of papers presented at the Conference on
Conference_Location :
Baltimore, MD, USA
Print_ISBN :
1-55752-662-1
DOI :
10.1109/CLEO.2001.947976
