Title :
Multifunctional lab-on-a-tube (LOT) probe for simultaneous neurochemical and electrophysiological activity measurements
Author :
Li, Cong ; Wu, P.M. ; Prince, S.J. ; Wu, Zhisheng ; Chakraborti, S. ; Ahn, Chong H. ; Hartings, J.A. ; Narayan, R.K.
Author_Institution :
Cushing Neuromonitoring Lab., Feinstein Inst. for Med. Res., New York, NY, USA
Abstract :
A multifunctional lab-on-a-tube (LOT) probe for simultaneous in vivo neurochemical and electrophysiological activity measurements is presented. Developed heterostructured platinum/iridium oxide (Pt/IrOx) microelectrodes have shown a superior signal-to-noise ratio and around 80 times slower polarization rate than platinum microelectrodes with the same surface area. Oxygen and glucose biosensors have been integrated to simultaneously detect their changes during cortical spreading depolarizations. The developed LOT shows minimum electrode crosstalk under optimized electrode design and placement, so it can improve the determination of cortical spreading depolarization causing brain injury with respect to multiple cerebral metabolic biomarkers.
Keywords :
bioelectric potentials; biomedical electrodes; biosensors; brain; electrochemical sensors; iridium compounds; microelectrodes; neurophysiology; oxygen; patient diagnosis; platinum; sugar; LOT probe; O; Pt-IrOx; brain injury; cerebral metabolic biomarker; cortical spreading depolarization; electrophysiological activity measurement; glucose biosensor; heterostructured microelectrode; in vivo measurement; multifunctional lab-on-a-tube probe; neurochemical activity measurement; optimized electrode design; oxygen sensor; Biosensors; Microelectrodes; Oxygen; Probes; Sugar; Neurochemical; electroencephalography; lab-on-a-tube; spreading depolarization;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on
Conference_Location :
Barcelona
DOI :
10.1109/Transducers.2013.6626908
