Title :
A multi-shank silk-backed parylene neural probe for reliable chronic recording
Author :
Fan Wu ; Lee Tien ; Fujun Chen ; Kaplan, David ; Berke, Joshua ; Euisik Yoon
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of Michigan, Ann Arbor, MI, USA
Abstract :
Many chronic brain implants would benefit from a neural probe with many densely configured electrodes with stable recording quality. We present a novel strategy to scale up the number of electrodes with minimized risk of proportionally increasing the adverse foreign body reactions. A flexible parylene probe having 64 electrodes has been designed and fabricated with unique geometries for reduced tissue reactions. Biocompatible silk fibroin was patterned to provide a biodegradable mechanical support of the flexible probe during insertion. We validated the design with in vivo recording in rats and observed no significant deterioration in recording quality for over 5 weeks.
Keywords :
biochemistry; biodegradable materials; biological tissues; biomedical electrodes; brain; molecular biophysics; neurophysiology; polymers; prosthetics; proteins; adverse foreign body reactions; biocompatible silk fibroin; biodegradable mechanical properies; chronic brain implants; chronic recording; electrodes; flexible parylene probe; multishank silk-backed parylene neural probe; tissue reactions; Electrodes; Fabrication; Geometry; Gold; In vivo; Probes; Silicon; Biocompatibility; Neural Probe; Parylene; Silk Fibroin;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on
Conference_Location :
Barcelona
DOI :
10.1109/Transducers.2013.6626910