Title :
Comparison of air and perfluorocarbon filled microbubbles for ultrasound contrast studies
Author :
Forsberg, Flemming ; Rawool, Nandkumar M. ; Merton, D.A. ; Liu, Ji-Bin ; Wang, Wenhua ; Kankate, Patma ; Alessandro, John ; Goldberg, Barry B. ; Wheatley, Margaret A.
Author_Institution :
Dept. of Radiol., Thomas Jefferson Univ. Hospital, Philadelphia, PA, USA
Abstract :
To evaluate the impact of different gasses on contrast studies a new contrast agent ST68 (US patent 5,352,436) was produced with either air (ST68-Air) or perfluorocarbon (ST68-PFC) filled microbubbles. ST68 was administrated to 11 rabbits. In 4 animals a qualitative comparison of duration and degree of enhancement was performed. ST68-PFC produced greater vascular enhancement than did ST68-PFC, Also, the former achieved gray scale enhancement unlike the latter. Enhancement with ST68-PFC lasted over 8 minutes, while ST68-Air lasted less than 2 minutes. Quantitative dose-responses (averaged over 5 injections) were calculated, via spectral power analysis, using data from 7 rabbits and a 10 MHz cuff-transducer placed around the distal aorta. Maximum enhancement with ST68-Air was 18.3 dB for a 0.13 ml/kg dose, while ST68-PFC produced 26.1 dB of enhancement for a 0.1 ml/kg dose. In conclusion, perfluorocarbon filled microbubbles appear to be superior to air filled ones for use in an ultrasound contrast agent
Keywords :
biomedical ultrasonics; bubbles; image enhancement; spectral analysis; 10 MHz; 2 min; 8 min; air filled microbubbles; contrast agent ST68; cuff-transducer; distal aorta; gray scale enhancement; medical diagnostic imaging; perfluorocarbon filled microbubbles; quantitative dose-responses; rabbits; ultrasound contrast studies; vascular enhancement; Animals; Apertures; Chemical engineering; Data analysis; Pharmaceuticals; Rabbits; Radiology; Spectral analysis; Ultrasonic imaging; Ultrasonic transducers;
Conference_Titel :
Ultrasonics Symposium, 1996. Proceedings., 1996 IEEE
Conference_Location :
San Antonio, TX
Print_ISBN :
0-7803-3615-1
DOI :
10.1109/ULTSYM.1996.584293
