MEMS scanner based handheld imaging guided Mohs surgery system

We demonstrate a handheld Mohs surgical probe coupling confocal imaging with projection for guided skin cancer removing. The probe consists of a miniaturized confocal microscope for in-vivo imaging, and a display system to track the real-time movement of tissue for the accurate determination of the projection area. Fast lissajous pattern laser scanning for confocal imaging was provided by a CMOS compatible 2-axis MEMS mirror. Lateral resolution of 6um with large field-of-view (FOV) of 1mm×0.5mm was achieved for the microscopic imaging at a speed of 2 frames-per-second (fps). Mosaic image with FOV of 4.8mm×6.2mm with high resolution demonstrates the system´s functionality for surgeon to diagnose interested disease. The system´s clinical imaging performance was further verified on histological human benign oral tissue, and compared with a commercial microscope. Effective projection performance was demonstrated with a close overlapping (over 87%) between the imaging & diagnosing area.