Title :
Embryo lab chip taking advantage of microfluidics and cell co-culturing
Author :
Cheng-Hsien Liu ; Kuo-Wei Chang ; Pei-Yu Chang ; Yi-Jung Sung ; Hong-Yuan Huang ; Da-Jeng Yao ; Shih-Kang Fan ; Wensyang Hsu ; Chin-Jung Li
Author_Institution :
Dept. of Power Mech. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
This research serves as an in vitro platform for fertilization and embryonic development. Thin polydimethylsiloxane (PDMS) membrane was etched to create an array of through-holes, and sandwiched between two PDMS channels to form an upper chamber and lower chamber. This device integrates the concentration gradient design and perfusion system for proposed embryo coculture with stromal cells.
Keywords :
bioMEMS; biomedical equipment; cellular biophysics; etching; haemorheology; lab-on-a-chip; membranes; microfluidics; polymers; PDMS channels; cell coculturing; concentration gradient design; embryo coculture; embryo lab chip; embryonic development; etching; fertilization; in vitro platform; microfluidics; perfusion system; stromal cells; thin polydimethylsiloxane membrane; through-hole array; Biomembranes; Embryo; In vivo; MIMICs; Mechanical engineering; Microfluidics; Simulation; Embryo Culture; Perfusion System; Porous Membrane; Three Dimensional Biomimetic Microsystem;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7181004
