Curvature effects on propagation in cardiac tissue

Author

Comtois, P. ; Vinet, A.

Author_Institution

Res. Centre, Hopital du Sacre-Coeur, Montreal, Que., Canada

Volume

1

fYear

1999

fDate

1999

Abstract

Simulations of reentry in 1D, 2D and 3D ionic models of cardiac excitable tissue have shown that the APD(DIA) curve is a major determinant of the stability of the propagation. Curvature is also an important factor in extended tissue and kinematical (KIN) models including K and rhythm dependence of Θ have been proposed. These models are incomplete since they do not include the effect of APD on the propagation. The authors´ objective was to find functions expressing the effect of K and DIA on Θ and APD, and to use these them to construct a more complete KIN model of propagation in 2D medium. The Θ(K,DIA) and APD(K,DIA) were obtained by fitting the results of simulations with a BRT ionic model, using an approximation of the 2D diffusion equation allowing a systematic exploration of K and DIA. The functions were used in a KIN model describing the propagation of period-1 solutions in a 2D ring of tissue

Keywords

bioelectric phenomena; cardiology; physiological models; 1D ionic model; 2D ionic model; 2D tissue ring; 3D ionic model; cardiac excitable tissue; cardiac tissue propagation; curvature effects; extended tissue model; kinematical model; rhythm dependence; Biomembranes; Boundary conditions; Cardiac tissue; Convergence; Equations; Financial advantage program; Level set; Morphology; Rhythm; Stability;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802204

Filename

802204