Increased tissue nitric oxide (NO) and cortical blood flow during functional activation of rat brain

Author

Buerk, Donald G. ; Ances, Beau M. ; Detre, John A. ; Greenberg, Joel H.

Author_Institution

Dept. of Physiol., Pennsylvania Univ., Philadelphia, PA, USA

Volume

1

fYear

1999

fDate

1999

Abstract

Tissue NO was measured in rat somatosensory cortex using NO-sensitive electrochemical microsensors during functional activation of the brain by electrical stimulation of the forepaw, while simultaneously measuring cortical blood flow by laser Doppler flowmetry. Increases in NO were observed, which preceded the rise in blood flow, suggesting that NO is involved in the coupling of blood flow with changes in neuronal activity

Keywords

biochemistry; bioelectric phenomena; blood flow measurement; brain; nitrogen compounds; somatosensory phenomena; NO; cortical blood flow; forepaw electrical stimulation; increased tissue nitric oxide; laser Doppler flowmetry; neuronal activity changes; rat brain functional activation; Biomedical engineering; Blood flow; Electric variables measurement; Electrical stimulation; Fluid flow measurement; Microsensors; Nervous system; Optical coupling; Physiology; Retina;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802443

Filename

802443