Title :
Increased tissue nitric oxide (NO) and cortical blood flow during functional activation of rat brain
Author :
Buerk, Donald G. ; Ances, Beau M. ; Detre, John A. ; Greenberg, Joel H.
Author_Institution :
Dept. of Physiol., Pennsylvania Univ., Philadelphia, PA, USA
Abstract :
Tissue NO was measured in rat somatosensory cortex using NO-sensitive electrochemical microsensors during functional activation of the brain by electrical stimulation of the forepaw, while simultaneously measuring cortical blood flow by laser Doppler flowmetry. Increases in NO were observed, which preceded the rise in blood flow, suggesting that NO is involved in the coupling of blood flow with changes in neuronal activity
Keywords :
biochemistry; bioelectric phenomena; blood flow measurement; brain; nitrogen compounds; somatosensory phenomena; NO; cortical blood flow; forepaw electrical stimulation; increased tissue nitric oxide; laser Doppler flowmetry; neuronal activity changes; rat brain functional activation; Biomedical engineering; Blood flow; Electric variables measurement; Electrical stimulation; Fluid flow measurement; Microsensors; Nervous system; Optical coupling; Physiology; Retina;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802443
