An ionic current model for respiratory neurons in the rat vNTS and guinea pig nucleus ambiguus

Author

Athanasiades, A. ; Clark, J.W., Jr. ; Ghorbel, F. ; Bidani, A.

Author_Institution

Sch. of Eng., Rice Univ., Houston, TX, USA

Volume

1

fYear

1999

fDate

1999

Abstract

Although other Hodgkin-Huxley type models have been developed for respiratory neurons, they have not been applied to quantitatively represent electrophysiological data. We present a neuron model that predicts the behavior of respiratory neurons both in the rat ventral nucleus tractus solitarius (vNTS) and the guinea pig nucleus ambiguous (NA). Within these regions neurons are classified according to specific patterns of behavior. Our simulations point to the mechanisms responsible for spike frequency adaptation (SFA), delayed excitation (DE), and postinhibitory rebound (PIR)

Keywords

bioelectric phenomena; neurophysiology; physiological models; Hodgkin-Huxley type models; NTS; delayed excitation; electrophysiological data; guinea pig nucleus ambiguous; ionic current model; neuron model; postinhibitory rebound; rat; rat ventral nucleus tractus solitarius; respiratory neurons; simulations point; spike frequency adaptation; Biomedical engineering; Biomembranes; Calcium; Data engineering; Delay; Frequency; Neurons; Predictive models; Roentgenium; Ventilation;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802477

Filename

802477