Nitric oxide releasing materials for the prevention of thrombosis and restenosis

Author

Bohl, K.S. ; West, J.L.

Author_Institution

Dept. of Bioeng., Rice Univ., Houston, TX, USA

Volume

2

fYear

1999

fDate

36434

Abstract

The goal of the current study was to synthesize biofunctional polymers that spontaneously release nitric oxide under physiological conditions. Such materials may have applications for the prevention of thrombosis and restenosis following arterial injury. We have synthesized two hydrogels that release nitric oxide (NO) with different release kinetics. There was evidence of NO release over a period of several weeks from NO-nucleophile complexes within hydrogels, while S-nitrosocysteine hydrogels displayed NO release over several hours

Keywords

biomedical materials; gels; nitrogen compounds; photochemistry; polymer blends; polymerisation; NO; NO-nucleophile complexes; S-nitrosocysteine hydrogels; arterial injury; biofunctional polymers; copolymer; hydrogels; nitric oxide releasing materials; photopolymerisation; physiological conditions; release kinetics; restenosis prevention; spontaneous NO release; synthesis; thrombosis prevention; Amino acids; Arteries; Biological materials; Biomedical engineering; Injuries; Kinetic theory; Material storage; Muscles; Polymers; Thrombosis;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.803874

Filename

803874