DocumentCode
347384
Title
Biosynthesis of intervertebral disc matrix in vitro
Author
Setton, L.A. ; Baer, A.E. ; Wang, Jia ; Kraus, V.B.
Author_Institution
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Volume
2
fYear
1999
fDate
36434
Abstract
Cells of the intervertebral disc are shown to express genes for aggrecan and collagen in an in vitro alginate culture system. Despite evidence for significant biosynthesis, the cells appear unable to assemble a mechanically functional matrix in this in vitro system
Keywords
bone; cellular biophysics; genetics; molecular biophysics; proteins; aggrecan; biosynthesis; cells; collagen; in vitro alginate culture system; intervertebral disc matrix in vitro; mechanically functional matrix; Assembly systems; Biomedical engineering; Biomedical measurements; Cells (biology); Gene expression; In vitro; In vivo; Materials testing; Medical treatment; Sparse matrices;
fLanguage
English
Publisher
ieee
Conference_Titel
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location
Atlanta, GA
ISSN
1094-687X
Print_ISBN
0-7803-5674-8
Type
conf
DOI
10.1109/IEMBS.1999.804494
Filename
804494
Link To Document