Title :
Simulating Biological Pathways with a Continuous Petri Net Using Runge-Kutta Methods
Author :
Kang, Sunku ; Lee, Byungwoo ; Yang, Jihoon ; Kim, Seonho ; Kim, Saejoon
Author_Institution :
Samsung Dept. of Comput. Sci., Sogang Univ., Seoul
Abstract :
The application of Petri nets to analyze and simulate biological pathways has been developed vigorously. Some of the modifications of Petri nets appeared to perform quantitative analysis of biological pathways: hybrid Petri net, timed Petri net, stochastic Petri net and so on. For a quantitative analysis of biological pathways, we propose to adopt Runge-Kutta methods to act on a continuous Petri net. We show that Runge-Kutta methods are applicable to a continuous Petri net in glycolysis and apoptosis pathways with reliable and efficient simulation results.
Keywords :
Petri nets; Runge-Kutta methods; biology computing; Runge-Kutta methods; apoptosis; biological pathway simulation; continuous Petri net; glycolysis; hybrid Petri net; stochastic Petri net; systems biology; timed Petri net; Analytical models; Biochemical analysis; Biological system modeling; Biology; Computational modeling; Computer simulation; Discrete event systems; Information technology; Petri nets; Stochastic processes;
Conference_Titel :
Frontiers in the Convergence of Bioscience and Information Technologies, 2007. FBIT 2007
Conference_Location :
Jeju City
Print_ISBN :
978-0-7695-2999-8
DOI :
10.1109/FBIT.2007.62
