Principal Component Analysis of Infectomes in Human Brain Endothelial Cell after C. neoformans Infection

Author

Jong, Ambrose Y. ; Feng, Luo ; Chen, Steven H M ; Huang, Sheng-He

Author_Institution

Div. of Hematology-Oncology, Children´´s Hosp. Los Angeles, Los Angeles, CA

fYear

2007

fDate

11-13 Oct. 2007

Firstpage

274

Lastpage

277

Abstract

Cell surface molecule CD44 of human brain microvascular endothelial cells (HBMEC) is the receptor of Cryptococcus neoformans during the infection. We performed microarray analysis and used principle component analysis to examine gene profiles of HBMEC in responses to C neoformans infection. The CD44 levels increases, peaking at the 4-hour time point and then declined gradually. Seventy genes displayed a similar gene profile. Our results showed a dynamic relationship between pathogen-host interactions. The data is useful for the analysis of invasion mechanism of C neoformans into HBMEC.

Keywords

brain; cellular biophysics; diseases; genetics; microorganisms; molecular biophysics; neurophysiology; principal component analysis; C. neoformans infection; Cryptococcus neoformans; cell surface molecule; endothelial cell; gene profiles; genes; human brain cell; infectomes; microarray analysis; microvascular cells; pathogen-host interactions; principal component analysis; time 4 hour; Cryptography; Gene expression; Hospitals; Humans; Information technology; Multidimensional systems; Pathogens; Performance analysis; Principal component analysis; Temperature sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Frontiers in the Convergence of Bioscience and Information Technologies, 2007. FBIT 2007

Conference_Location

Jeju City

Print_ISBN

978-0-7695-2999-8

Type

conf

DOI

10.1109/FBIT.2007.134

Filename

4524118