Title :
Assessment of baroreflex control of heart rate during general anesthesia using a point process method
Author :
Chen, Zhe ; Purdon, Patrick L. ; Pierce, Eric T. ; Harrell, Grace ; Brown, Emery N. ; Barbieri, Riccardo
Author_Institution :
Neurosci. Stat. Res. Lab., Harvard Med. Sch., Boston, MA
Abstract :
Evaluation of baroreflex control of heart rate (HR) has important implications in clinical practice of anesthesia and postoperative care. In this paper, we present a point process method to assess the dynamic baroreflex gain using a closed-loop model of the cardiovascular system. Specifically, the inverse Gaussian probability distribution is used to model the heartbeat interval, whereas the instantaneous mean is identified by a linear or bilinear bivariate regression on the previous R-R intervals and blood pressure (BP) measures. The instantaneous baroreflex gain is estimated in the feedback loop with a point process filter, while the RRrarrBP feedforward frequency response is estimated by a Kalman filter. In addition, the instantaneous cross-spectrum and cross-bispectrum (as well as their ratio) can also be estimated. All statistical indices provide a valuable quantitative assessment of the interaction between heartbeat dynamics and hemodynamics during general anesthesia.
Keywords :
cardiology; medical control systems; medical signal processing; baroreflex control assessment; bilinear bivariate regression; blood pressure measures; cardiovascular system; clinical practice; general anesthesia; heart rate control; heartbeat dynamics; heartbeat interval; hemodynamics; inverse Gaussian probability distribution; point process method; postoperative care; Anesthesia; Baroreflex; Blood pressure; Cardiovascular system; Feedback loop; Frequency estimation; Heart beat; Heart rate; Pressure measurement; Probability distribution; Volterra series; adaptive filters; baroreflex control; bilinear systems; point processes;
Conference_Titel :
Acoustics, Speech and Signal Processing, 2009. ICASSP 2009. IEEE International Conference on
Conference_Location :
Taipei
Print_ISBN :
978-1-4244-2353-8
Electronic_ISBN :
1520-6149
DOI :
10.1109/ICASSP.2009.4959588