Title :
On the Effectiveness of Distances Measuring Protein Structure Similarity
Author :
Galgonek, Jakub ; Hokzsa, David
Author_Institution :
Dept. of Software Eng., Charles Univ. in Prague, Prague, Czech Republic
Abstract :
Determining similarity between two protein structures is one of the most fundamental problems in contemporary structural bioinformatics. With the increasing complexity of the measures, their effectiveness increases as well. However, other important observables, such as the degree of metric properties fulfilment, could rather deteriorate than improve. In this paper we introduce an effective measure and study its degree of metric properties fulfilment.
Keywords :
bioinformatics; molecular biophysics; proteins; contemporary structural bioinformatics; measurement complexity; metric properties; protein structure similarity; Amino acids; Application software; Bioinformatics; Databases; Heuristic algorithms; Mathematics; Physics; Protein engineering; Software engineering; Software measurement; Protein Structure; SCOP; TM-score;
Conference_Titel :
Similarity Search and Applications, 2009. SISAP '09. Second International Workshop on
Conference_Location :
Prague
Print_ISBN :
978-0-7695-3765-8
DOI :
10.1109/SISAP.2009.19