Title :
CCD based ion image sensors for novel bio imaging — Fusion of Sensor technology and LSI technology
Author_Institution :
Dept. of Electr. & Electron. Inf. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan
Abstract :
The ion image sensor was invented. The device enables two dimensional visualization of both the ion and optical imaging of chemical activity of solutions and cell activity. The CMOS device consists of an array of CCDs covered with functionalized membrane. Changes in the concentration and two dimensional distributions of several ions are detected by charge accumulation. We have recently reported on the use of the sensor for real time imaging of acetylcholine (ACh) enzyme reactions. Insights in the variation of the concentration of ACh may lead to new methods for the treatment of Alzheimer´s disease.
Keywords :
biomedical imaging; biosensors; image sensors; large scale integration; Alzheimer´s disease; CCD; CMOS device; LSI technology; acetylcholine enzyme reactions real time imaging; bio imaging; cell activity; ion image sensors; ion imaging; optical imaging; sensor technology fusion; solutions chemical; Biomedical optical imaging; Image sensors; Optical device fabrication; Optical imaging; Optical sensors; Acetylcholine; CCD devices; CMOS image sensors; Ion image sensors; Non label imaging;
Conference_Titel :
Optical MEMS and Nanophotonics (OMN), 2012 International Conference on
Conference_Location :
Banff, AB
Print_ISBN :
978-1-4577-1511-2
DOI :
10.1109/OMEMS.2012.6318879
