Title :
Multiple reaction monitoring: Modeling and systematic analysis
Author :
Atashpaz-Gargari, Esmaeil ; Braga-Neto, Ulisses M. ; Dougherty, Edward R.
Author_Institution :
Dept. of Electr. & Comput. Eng., Texas A&M Univ., College Station, TX, USA
Abstract :
Mass Spectrometry in Multiple Reaction Monitoring (MRM) mode is becoming increasingly used in the validation of protein biomarkers. In a systematic approach toward studying MRM, in this paper, the biomarker validation pipeline using this method is modeled. Numerical experiments based on this model are used to study the effect of different parameters on the final performance of biomarker validation.
Keywords :
biochemistry; mass spectroscopic chemical analysis; molecular biophysics; physiological models; proteins; biomarker validation pipeline; mass spectrometry; multiple reaction monitoring; protein biomarkers; systematic analysis; Biological system modeling; Biomarkers; Monitoring; Noise; Peptides; Protein engineering; Proteins;
Conference_Titel :
Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on
Conference_Location :
San Antonio, TX
Print_ISBN :
978-1-4673-0491-7
Electronic_ISBN :
2150-3001
DOI :
10.1109/GENSiPS.2011.6169455
