Title :
Integrated microfluidic oxygenator bundles for blood gas exchange in premature infants
Author :
Rochow, Niels ; Wu, Wen-I ; Chan, Emily ; Nagpal, Dipen ; Fusch, Gerhard ; Selvaganapathy, P. Ravi ; Monkman, Shelley ; Fusch, Christoph
Author_Institution :
Dept. of Pediatrics, Div. of Neonatology, McMaster Univ., Hamilton, ON, Canada
fDate :
Jan. 29 2012-Feb. 2 2012
Abstract :
This paper reports the development of a low volume pumpless lung assist device (LAD) composed of a stack of microfluidic single oxygenators units (SOUs) connected in parallel. SOUs are comprised of a microfluidic vascular network (polydimethylsiloxane) and a gas-permeable polycarbonate (PC) membrane to enhance gas exchange between blood and ambient air. We report results from an in vitro test and the first performance test of the LAD in hypoxic newborn piglet in which we show an increase of up to 40% in peripheral oxygen saturation.
Keywords :
bioMEMS; biomedical equipment; blood; lung; microfluidics; paediatrics; pneumodynamics; LAD; blood gas exchange; gas-permeable polycarbonate membrane; hypoxic newborn piglet; in-vitro test; integrated microfluidic oxygenator bundles; low volume pumpless lung assist device; microfluidic single oxygenator units; microfluidic vascular network; peripheral oxygen saturation; polydimethylsiloxane; premature infants; Biomembranes; Blood; Blood flow; Lungs; Microfluidics; Pediatrics; Performance evaluation;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on
Conference_Location :
Paris
Print_ISBN :
978-1-4673-0324-8
DOI :
10.1109/MEMSYS.2012.6170345
