Study of morphological changes of neuroblastoma cells induced by activation of NMDA receptor

Author

Yuqiang Fang ; Lai, King W. C. ; Iu, Catherine Y. Y. ; Lui, Cathy N. P. ; Fung, Carmen K. M. ; Hung-Wing Li ; Yung, Ken K. L. ; Xi, Ning

Author_Institution

Dept. of Mech. & Biomed. Eng., Hong Kong Baptist Univ., Hong Kong, China

fYear

2013

fDate

10-13 Nov. 2013

Firstpage

83

Lastpage

86

Abstract

Neurodegeneration has been recognized as the main cause for neuronal diseases. Much effort has been paid to investigate the process of neurodegeneration from the viewpoint of molecular biology. However, the mechanisms of some processes are still unclear. Here we use a new means to study neurodegeneration using atomic force microscopy (AFM) from the aspect of cellular integrity. The morphological information of neuroblastoma cells was obtained by AFM and it showed a great difference in the process of neurodegeneration induced by activation of NMDA receptors.

Keywords

atomic force microscopy; cellular biophysics; diseases; medical disorders; molecular biophysics; neurophysiology; proteins; surface morphology; AFM; NMDA receptor activation; atomic force microscopy; cellular integrity; molecular biology; morphological changes; morphological information; neuroblastoma cells; neurodegeneration; neurodegeneration process; neuronal diseases; Diseases; Microscopy; Proteins; Rough surfaces; Surface morphology; Surface roughness; Surface treatment; AFM; Cytoskeleton; NMDA receptor; morphology; neurodegeneration;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Molecular Medicine and Engineering (NANOMED), 2013 IEEE 7th International Conference on

Conference_Location

Phuket

Print_ISBN

978-1-4799-2689-3

Type

conf

DOI

10.1109/NANOMED.2013.6766320

Filename

6766320