Title :
The presence of old Alus in GC-rich regions of the human genome - a genetic algorithm perspective
Author :
Anastasoff, S.J.
Author_Institution :
Univ. of Birmingham, UK
Abstract :
More than 10% of the human genome is comprised of a sequence known as an Alu repeat, with over a million copies of this distributed throughout our DNA. Detailed analysis of the distribution of this sequence shows it to be dispersed in an unusual way. In the work presented here, a genetic algorithm simulation was developed as the basis for modeling transposons (of which the Alu is one type). This simulation was used to explore the evolutionary conditions under which such a distribution could arise
Keywords :
DNA; biology computing; evolution (biological); genetic algorithms; physiological models; Alus; DNA; evolutionary conditions; genetic algorithm; human genome; sequence distribution; simulation; transposon distributions; Biochemistry; Bioinformatics; DNA; Genetic algorithms; Genomics; Humans; Organisms; Sequences;
Conference_Titel :
Evolutionary Computation, 2002. CEC '02. Proceedings of the 2002 Congress on
Print_ISBN :
0-7803-7282-4
DOI :
10.1109/CEC.2002.1006201
