DocumentCode :
3562072
Title :
Lower instantaneous entropy of heartbeat dynamics characterizes cognitive impairment in Parkinson´s disease
Author :
Barbieri, Riccardo ; Valenza, Gaetano ; Citi, Luca ; Guerrisi, Maria ; Orsolini, Stefano ; Tessa, Carlo ; Diciotti, Stefano ; Toschi, Nicola
Author_Institution :
Harvard Med. Sch., Massachusetts Gen. Hosp., Boston, MA, USA
fYear :
2014
Firstpage :
81
Lastpage :
84
Abstract :
It has been estimated that the incidence of cognitive deficits in Parkinson´s disease (PD), ranging from Mild Cognitive Impairment (MCI) to frank dementia, is six-fold compared to that in the general population. Also, PD involves postganglionic sympathetic failure and, in 25% of patients, autonomic failure. PD patients commonly present a range of ANS-dysfunction related symptoms. Since cognitive impairment has been previously linked with cardiovascular dysautonomia in PD, in this paper we investigate whether a link exists between autonomic complexity and MCI in PD. To this end, we employ our recently developed instantaneous measures of complexity, which have been explicitly designed for stochastic time series with binary events that occur in continuous time: the inhomogeneous point-process approximate and sample entropy (ipApEn and ipSampEn, respectively). Experimental results obtained by comparing 8 cognitively preserved (PD-NC) to 8 PD-MCI subjects during resting state demonstrate that grand average values of ipSampEn are able to differentiate the two groups. This suggests that a significant loss of time-varying cardiovascular complexity is associated with MCI in PD. Importantly, no other heart rate variability (HRV) measures differed significantly between groups, possibly pointing toward subtle autonomic changes (not detectable through conventional HRV analysis) which accompany the initial stage of cognitive impairment in PD.
Keywords :
cardiovascular system; cognition; diseases; medical disorders; neurophysiology; stochastic processes; time series; ANS-dysfunction related symptoms; HRV measurement; MCI; PD patients; PD-MCI; PD-NC; Parkinson disease; autonomic failure; frank dementia; heart rate variability measurement; heartbeat dynamics; inhomogeneous point-process approximation; ipApEn entropy; ipSampEn entropy; lower instantaneous entropy; mild cognitive impairment; postganglionic sympathetic failure; stochastic time series; time-varying cardiovascular complexity; Abstracts; Computational modeling; Hafnium; Indexes; Nonhomogeneous media; Physiology; Vectors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computing in Cardiology Conference (CinC), 2014
ISSN :
2325-8861
Print_ISBN :
978-1-4799-4346-3
Type :
conf
Filename :
7042984
Link To Document :
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