Title :
Isolation of bioactive compounds from marine mollusk against human pathogens
Author :
Chellaram, C. ; John, A. Alex
Author_Institution :
Dept. of Biomed. Eng., Vel Tech Multitech Dr. Rangarajan Dr. Sakunthala Eng. Coll., Chennai, India
Abstract :
The present study involved the isolation and structural elucidation of the active constituent of gastropod, Drupa margariticola extract using different Chromatographic techniques and various tools of spectral analysis. The acetone phase of the D. margariticola showed promising activity indicating the presence of active fractions. The active compound, diterpenoid acylglycerol which has been isolated from the gastropod, Drupa margarüicola exhibited broad spectral activity against Salmonella typhimurium, Vibrio cholerae, Bacillus subtilis, with inhibitory zones of 8 mm, 8 and 8 mm, respectively at a concentration of 50μg.
Keywords :
antibacterial activity; biomedical materials; chromatography; materials preparation; organic compounds; Bacillus subtilis; D. margariticola; Drupa margariticola extract; Salmonella typhimurium; Vibrio cholerae; acetone phase; active constituent; active fractions; bioactive compound isolation; chromatographie techniques; diterpenoid acylglycerol; gastropod; human pathogens; inhibitory zones; margarüicola; marine mollusk; mass 50 mug; spectral activity; spectral analysis; structural elucidation; Antibacterial activity; Chemicals; Compounds; Nuclear magnetic resonance; Organisms; Pathogens; Solvents; Antibacterial Activity; Marine mollusk; Structural elucidation;
Conference_Titel :
Science Engineering and Management Research (ICSEMR), 2014 International Conference on
Print_ISBN :
978-1-4799-7614-0
DOI :
10.1109/ICSEMR.2014.7043643
