Numerical simulation of magnetic drug localization in the knee joint medication

Medication used in the therapy of joints is generally routed via either oral or parenteral leads and delivery techniques are prone to systemic adverse effects that may be overcome through intra-articular administration of the medication into the region of interest (ROI). The concern related to the fast vanishing of medication off the joint is overcome through the encapsulation of the drug and the corticosteroid with superparamagnetic (iron oxide) nanoparticles (SPION), which confer magnetic properties that may be used to localize the medication through an external magnetic field. This paper presents numerical simulation results for the SPION magnetic drug targeting (SPION-MDT) used to treat a knee joint condition using 2D (CAD), and 3D (by reconstruction techniques) computational domains that represent the knee joint region of an adult. A magnetic field may effectively act upon the SPION medication, retaining it into the ROI.