Title :
A computational model of STP and LTP for gene level signaling cascade in human episodic memory
Author :
Triapthi, Sudhakar ; Mishra, R.B.
Author_Institution :
Dept. of Comput. Sci. & Eng., Indian Inst. of Technol. (BHU), Varanasi, India
Abstract :
In this paper a computational model of gene level signaling for STP (Short Term Potentiation) and LTP (Long Term Potentiation) have been proposed. STP and LTP are prime signaling cascade for establishment of Episodic Memory in human brain. In various previous works receptor level signaling cascades are presented for STP and LTP. In this work signaling cascade at gene level through gene-gene interaction of various receptor gene clusters are presented and simulated. The signaling cascade computational model would be helpful in estimating the activity of various genes for episodic memory, related disorders and their management through drugs and gene therapy.
Keywords :
biology computing; genetics; molecular biophysics; neural nets; LTP computational model; STP computational model; drugs; episodic memory management; gene level signaling cascade; gene therapy; gene-gene interaction; human episodic memory; long term potentiation; receptor level signaling cascade; short term potentiation; Analytical models; Calcium; Computational modeling; Electric potential; Mathematical model; Memory management; Proteins; Episodic Memory; Episodic Memory Signaling cascade; Episodic memory pathways; Gene level LTP signaling; LTP; STP;
Conference_Titel :
Computer Science and Engineering (APWC on CSE), 2014 Asia-Pacific World Congress on
Print_ISBN :
978-1-4799-1955-0
DOI :
10.1109/APWCCSE.2014.7053835
