Title :
A fast CEA analyzer prototype for point of care testing
Author :
Chua-Chin Wang ; Chiang-Hsiang Liao ; Chia-Ming Chang ; Je-Wei Lan ; Huang, I.-Yu.
Author_Institution :
Dept. of Electr. Eng., Nat. Sun Yat-Sen Univ., Kaohsiung, Taiwan
Abstract :
A CEA (carcinoembryonic antigen) concentration analyzer prototype using a pair of two-port FPW (flexural plate-wave) sensors is proposed in this paper. The proposed prototype utilizes a frequency-shift readout method based upon a peak detecting scheme to measure the resonant frequency shift. The frequency-shift readout circuit is integrated on silicon composed of a linear frequency generator, two peak detectors, two registers, and a subtractor. The frequency scanning range is from 0.9 MHz to 22.4 MHz according to the characteristics of the FPW biosensor. The sensitivity of the peak detector is 5 mV. The proposed frequency-shift readout circuit is verified by a PCB-based prototype, where the CEA serum titration is stabilized after 10 minutes and the linearity of the concentration vs. frequency shift is 97.72%.
Keywords :
biomedical measurement; biosensors; cancer; cellular biophysics; elastic waves; electron device testing; flip-flops; frequency shift keying; patient diagnosis; peak detectors; readout electronics; silicon; CEA concentration analyzer prototype; CEA serum titration; FPW biosensor; PCB-based prototype; carcinoembryonic antigen serum titration; concentration-frequency shift linearity; fast CEA analyzer prototype; flexural plate-wave biosensor; frequency 0.9 MHz to 22.4 MHz; frequency generator peak detectors; frequency generator registers; frequency generator subtractor; frequency-shift readout circuit; frequency-shift readout method; linear frequency generator; peak detecting scheme; peak detector sensitivity; point of care testing; resonant frequency shift measurement; time 10.00 min; two-port FPW; two-port flexural plate-wave sensors; voltage 5.00 mV; Biosensors; Cancer; Detectors; Frequency measurement; Prototypes; Resonant frequency; CEA measurement; FPW; frequency-shift readout circuit; point of care testing (POCT); resonant frequency;
Conference_Titel :
Electron Devices and Solid-State Circuits (EDSSC), 2014 IEEE International Conference on
DOI :
10.1109/EDSSC.2014.7061143
