Author_Institution :
Biomed. Syst. & Inf. Eng. Dept., Yarmouk Univ., Irbid, Jordan
Abstract :
Annually, a lot of patients in Canadian hospitals are contaminated with antibiotic-resistant bacteria, resulting in abundant amounts of money spent on the health-care system. Even though most bacteria are risk-free to healthy individuals, the symptoms of bacterial contamination can be severe for patients with a weakened immune system. Early detection is critical for improved patient care and can help in minimizing the risk of cross contamination between patients. This work aims at using state-of-the-art technologies for developing handheld multibiosensors on a single chip for pathogenic bacteria detection. There is extensive demand for a low-cost, rapid, selective and sensitive method for detecting bacteria in medical diagnosis, and food-safety inspection. In this work, we are introducing more than one technique based on a CMOS/MEMS technology batch process for detecting pathogen bacterial cell at a low concentration level. The methodology of the proposed multi-labs-on-a-single-chip system (MLoC) lies on miniaturizing transducers, which is utilizing a sort of technique that has the capability to smooth the progress of point-of-care testing (POCT) and become conscious state-of-the-art molecular analysis independently of the state-of-the-art laboratory. MLoC methodology can be categorized as electrochemical, capacitive and optical, on the light of their sensing theory, incorporated with interdigitated microelectrode array (IDMA).
Keywords :
bioMEMS; biomedical measurement; biomedical transducers; biosensors; chemical sensors; food safety; lab-on-a-chip; microorganisms; molecular biophysics; patient diagnosis; CMOS/MEMS technology batch process; Canadian hospital patients; IDMA; MLoC methodology; POCT progress; antibiotic-resistant bacteria; bacteria-contaminated patients; bacterial contamination symptoms; bacterial contamination-associated food-safety inspection; bacterial contamination-associated medical diagnosis; biomedical biosensors; capacitive bacterial contamination assessment methodology; cross contamination risk; early bacterial contamination detection; electrochemical bacterial contamination assessment methodology; handheld multibiosensors; health-care system; improved patient care; interdigitated microelectrode array; low bacterial concentration level; low-cost bacterial detection method; miniaturized transducers; minimized bacterial contamination; multi-labs-on-a-single-chip system; optical bacterial contamination assessment methodology; pathogen bacterial cell detection; pathogenic bacterial detection; point-of-care testing progress; rapid bacterial detection method; risk-free bacteria; selective bacterial detection method; sensing theory; sensitive bacterial detection method; severe bacterial contamination; single-chip multibiosensors; state-of-the-art laboratory; state-of-the-art molecular analysis; state-of-the-art technologies; weakened patient immune system; Arrays; Biomedical optical imaging; Biosensors; CMOS integrated circuits; Electrodes; Microorganisms; Phototransistors; CBCM; EIS; ID; MLoC; Magnetic; Multibiosensors; Optical;