Comparative proteomics of Drosophila indirect flight muscle and tergal depressor of the trochanter to determine expression of troponin isoforms

Stretch activation (SA) is a delayed increase in force generation in response to muscle stretch that occurs to various degrees in all muscle types. The mechanism behind SA is unknown, but likely involves a thin filament mechanism. Therefore, more information about thin filament proteins involved in muscle contraction is needed. Results comparing muscles with very high and almost no SA capabilities show a preliminary difference in troponin I (TnI); however, tests with higher resolution and specificity are planned to further elucidate the connection between key muscle proteins and SA.