Title :
Nanosecond pulsed electric field interactions with microglia and astrocytes
Author :
Salah Sommakia;Season Wyatt;Kevin Otto;Anand Vadlamani;Allen L. Garner
Author_Institution :
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN
fDate :
6/1/2014 12:00:00 AM
Abstract :
Pulsed electrical fields (PEFs) that weaken the integrity of cellular membranes have been used for a variety of biomedical applications. Recent work suggests that nanosecond PEFs (nsPEFs) might be more beneficial than longer duration PEFs due to their slightly different mechanism of interaction with the cells. The nervous system presents an attractive, yet underutilized, biological target for nsPFE applications. In this paper we describe an in vitro primary mixed cortical cell system to test the effects of nsPFEs.
Keywords :
"Biomembranes","Nanobioscience","Electric fields","Cells (biology)","Electric potential","Neurons","Electrodes"
Conference_Titel :
Power Modulator and High Voltage Conference (IPMHVC), 2014 IEEE International
Print_ISBN :
978-1-4673-7323-4
DOI :
10.1109/IPMHVC.2014.7287296