A model-based method to evaluate autonomic regulation of cardiovascular system

Quantitative measures of autonomic regulation of cardiovascular system have clinical and prognostic value in a variety of cardiovascular diseases. This paper proposes a model-based method in the measurement of baroreflex sensitivity, sympathetic and parasympathetic activity. The method measures the continuous blood pressure and heart rate in orthostatic scenario, models the baroreflex and sympathetic regulation process, solves for personalized model parameters by optimization using measured blood pressure and heart rate variations. Experimental results have shown the validation of the quantitative measures and the effectiveness of the method.