Terahertz dynamics of amorphous (Bio) pharmaceutical mixtures

The molecular dynamics of amorphous materials and its relation to the physico-chemical changes in the organic glasses is still a topic of a dispute in the scientific community. Terahertz spectroscopy however provides very important experimental evidence on the fast dynamics in the overlapping region between the molecular relaxations and structural excitations, which is extremely sensitive to both dynamical and structural changes in the amorphous systems. We show how this information can be utilised to enhance the long-term stability of amorphous pharmaceutical systems and cryo-preserved proteins.