Disc segmentation and BMO-MRW measurement from SD-OCT image using graph search and tracing of three bench mark reference layers of retina

Spectral Domain Optical Coherence Tomography (SD-OCT) imaging is a robust diagnostic tool for visualizing pathology in the retina for glaucoma and other diseases. Bruch´s Membrane Opening minimum rim width (BMO-MRW) of retina is a good measurable marker for distinguishing glaucoma and normal individuals. In this paper, we have proposed a novel automatic method to compute BMO-MRW from segmenting the Inner limiting membrane (ILM) and Bruch´s Membrane Opening (BMO). Our technique uses the location tracking of three bench mark reference (TBMR) layers of the retina that reduce search space with improving accuracy. This also allows locating the boundary of the optic disc. The accuracy was tested against manually detected disc boundary for 13 subjects. The precision, recall and F1 score shows more than 95% for disc area and unsigned mean error rate of BMO-MRW is 58.62 db 43.12 (Mean ± SD) μm.