Modeling effects of nitric oxide on oxygen consumption in the microcirculation

Author

Lamkin-Kennard, Kathleen ; Buerk, Donald G. ; Barbee, Kenneth ; Wootton, David ; Jaron, Dov

Author_Institution

Dept. of Mech. Eng., Drexel Univ., Philadelphia, PA, USA

fYear

2002

fDate

2002

Firstpage

31

Lastpage

32

Abstract

Nitric oxide (NO) is a powerful vasodilator that regulates blood flow and inhibits mitochondrial oxygen (O₂) consumption. We present a mathematical model to show the effects NO has on the regulation of oxygen consumption in the microcirculation. We use expressions based on experimental data to simulate the steady state coupled mass transport of O₂ and NO through blood vessels, the vascular wall, and tissue. Our preliminary modeling studies, using a cylindrical geometry, show that the inhibition of O₂ consumption by NO increases tissue PO₂ farther from the vessel, The effect is more pronounced at lower PO₂ values

Keywords

biodiffusion; blood; blood vessels; haemodynamics; nitrogen compounds; physiological models; NO; arterioles; biotransport; blood flow; blood vessels; capillaries; concentration profiles; cylindrical geometry; layered structure; mathematical model; microcirculation; modified Michaelis-Menten kinetics; nitric oxide vasodilator effects; one-dimensional radial diffusion equation; oxygen consumption regulation; pseudo-first-order rate constant; reversible inhibitor; scavenging; steady state coupled mass transport; tissue; vascular endothelium; vascular wall; Blood flow; Equations; Geometry; Mathematical model; Oxygen; Plasma simulation; Plasma sources; Power engineering and energy; Solid modeling; Steady-state;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast

Conference_Location

Philadelphia, PA

Print_ISBN

0-7803-7419-3

Type

conf

DOI

10.1109/NEBC.2002.999450

Filename

999450