A novel microdialysis glucose sensor system based on co-immobilizing on Au micro-electrode by sol-gel technique

Author

Yu, Ping ; Liu, Weiting ; Chen, Yuquan ; Li, Guang

Author_Institution

Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou, China

Volume

3

fYear

2001

fDate

2001

Firstpage

3087

Abstract

A microdialysis sensor system for continuous glucose measurements has been developed. The sensor is based on co-immobilizing glucose oxidase (GOD) with the catalase by a sol-gel technique on the surface of silicon bases with two pattern of Au microelectrodes. A graduated ("sandwich") immobilizing method is performed to improve the stability and the lifetime of the co-enzyme system. The response of the system was in good order. Above all, we developed a new geometry of the bispiral microelectrode with numerical analysis of its electrochemical character.

Keywords

biomedical electrodes; biomedical transducers; biosensors; electrochemical electrodes; electrochemical sensors; microelectrodes; organic compounds; patient monitoring; sol-gel processing; Au; Au micro-electrode; Au microelectrodes; Si; bispiral microelectrode; catalase; coenzyme system lifetime; continuous glucose measurements; continuous glucose monitoring; diabetes clinical management; electroanalytcal chemistry; electrochemical character; glucose oxidase co-immobilization; graduated immobilizing method; microdialysis glucose sensor system; numerical analysis; sandwich immobilizing method; silicon surface; sol-gel technique; stability; Biomedical measurements; Biosensors; Electrodes; Gold; Insulation; Microelectrodes; Monitoring; Sensor systems; Stability; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1017454

Filename

1017454