High throughput challenges in molecular cell biology: the CELL MAP

Author

Bergeron, John J.M. ; Desjardins, Miche ; Thomas, David Y. ; Kearney, Robert E.

Author_Institution

McGill Univ., Montreal, Que., Canada

Volume

4

fYear

2001

fDate

2001

Abstract

Summary form only given. The complete elucidation of the protein complement of all compartments of the eukaryotic cell is under way. This poses logistical problems in sample preparation and high throughput but exhaustive characterization. Using examples of protein characterization of organelles by mass spectrometry and the validation of protein function by DNA chips, the engineering and bioinformatics challenges in proteomics and genomics are illustrated.

Keywords

DNA; biocybernetics; biological specimen preparation; cellular biophysics; genetics; mass spectroscopic chemical analysis; molecular biophysics; proteins; CELL MAP; DNA chips; bioinformatics challenges; engineering challenges; eukaryotic cell compartments; exhaustive characterization; genomics; high throughput challenges; logistical problems; mass spectrometry; molecular cell biology; organelles; protein characterization; protein complement; protein function; proteomics; sample preparation; Bioinformatics; Biological cells; DNA; Genomics; Mass spectroscopy; Protein engineering; Proteomics; Throughput;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1019745

Filename

1019745