Synonymous codon usage in genes coding for proteins with different folding types

195 genes coding for proteins in four different folding types have been analyzed in terms of variance analysis, in which there are 50 genes coding for all alpha proteins, 66 entries for all beta proteins, 37 entries for alpha+beta proteins and 42 entries for alpha/beta proteins. We have observed that codon usage in different gene classes coding for differently folded proteins is significantly different. Similar to amino acid propensities in different protein classes, folding type specific proteins have specific codon usage patterns. With the help of codon usage pattern, we can improve the accuracy of prediction of protein folding type and further prediction of protein secondary structure.