Title :
Modelling pharmacological block of rapid delayed rectifier current by E-4031 in sinoatrial pacemaker cells
Author :
Dokos, S. ; Boyett, M.R. ; Cloherty, S.L. ; Lovell, N.H.
Author_Institution :
Graduate Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia
Abstract :
We have developed a new mathematical model of single cell rabbit sinoatrial node pacemaker activity, employing Markov state kinetic descriptions of ionic currents. Parameters of the model have been adjusted to match experimental recordings of free running action potentials from the periphery of the node, recorded both in the absence and presence of E-4031-a selective blocker of the rapid delayed rectifier K+ current (iK,r). Results from the model suggest that the effects of E-4031 on action potential waveshape can be reproduced by simply lowering the membrane conductance of iK,r.
Keywords :
Markov processes; bioelectric potentials; biomembrane transport; cardiology; physiological models; potassium; E-4031; K+; K+ current; Markov state kinetic descriptions; action potential waveshape; cardiac action potentials; free running action potentials; ionic currents; mathematical model; membrane conductance; node periphery; pharmacological block modelling; rapid delayed rectifier current; selective blocker; single cell rabbit sinoatrial node pacemaker activity; sinoatrial pacemaker cells; Biomedical engineering; Biomembranes; Delay; Kinetic theory; Mathematical model; Pacemakers; Rabbits; Rectifiers; Storage area networks; Voltage;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106420
