Bioartificial liver support system

Author

Li, Ming ; Sun, Junhong ; Huo, Rongling ; Zhao, Yiyang ; Mu, Zhongxue ; Feng, Hueifen

Author_Institution

Inst. of Electr. Eng., Acad. Sinica, Beijing, China

Volume

2

fYear

2002

fDate

2002

Firstpage

1696

Abstract

A new bioartificial liver support system has been developed for the treatment of liver failure. The basis of the system is that the complex functions of the liver are replaced by hepatocytes cultured in a special bioreactor. The system consists of two circuits: the patient circuit and the bioreactor circuit. Fluids in the circuits dialyse against each other through the semipermeable membranes of hollow-fibres in a dialysis cartridge. Toxic molecules from the patient pass across the membrane and are metabolised by hepatocytes cultivated in the bioreactor while hepatocyte-synthesised products pass across the membrane to the patient in the opposite direction.

Keywords

artificial organs; biochemistry; biomimetics; cellular biophysics; filtration; liver; membranes; bioartificial liver support system; bioreactor circuit; complex functions; dialysis cartridge; fluid dialysis; hepatocyte-synthesised products; hepatocytes; hollow-fibres; liver failure; patient circuit; semipermeable membranes; special bioreactor; toxic molecules; Biomembranes; Bioreactors; Circuits; Control systems; Instruments; Liquid crystal displays; Liver; Medical control systems; Medical treatment; Microprocessors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106607

Filename

1106607