Culturing smooth muscle cells on modified PDMS substrates

Author

Li, Meng ; Ai, H. ; Mills, D.K. ; Lvov, Y.M. ; Gale, Bruce K. ; McShane, M.J.

Author_Institution

Inst. for Micromanufacturing, Louisiana Tech. Univ., Ruston, LA, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

388

Abstract

Polydimethylsiloxane (PDMS) is a popular biocompatible material to be used in cell culture area. However, due to its hydrophobic surface property, cells cannot grow on its bare surface very well. In this paper, electrostatic layer-by-layer (LbL) self-assembly technology was used to coat thin films of hydrophilic and biocompatible materials, poly(dimethyldiallylammonium chloride) (PDDA), poly(styrene sulfonate) (PSS), and gelatin, on the surface of cell culture substrate to increase the growth and alignment of smooth muscle cells (SMCs).

Keywords

biomedical materials; cellular biophysics; muscle; polymers; biocompatible materials; cell growth increase; gelatin; hydrophilic materials; layer-by-layer self-assembly; microfabrication; modified PDMS substrates; poly(dimethyldiallylammonium chloride); poly(styrene sulfonate); smooth muscle cells culturing; thin films coating; tissue engineering; Assembly; Biological materials; Biomedical engineering; Electrostatics; Microchannel; Muscles; Nonhomogeneous media; Optical microscopy; Self-assembly; Surface treatment;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1136858

Filename

1136858