Analysis of acoustical responses of microbubbles for the optimization of phase- and amplitude-coded pulse sequences

We have previously introduced an algorithm for the design of receive filters that are used with coded pulse sequences to enhance the contrast between two media, where one filter per pulse in the sequence is derived from training data. Following this approach, we tackled the question of what pulse sequence, considering amplitude and phase coding, is best suited for contrast agent imaging. We also solved the problem that filters of increasing length improve image contrast at the expense of bandwidth by means of non-liner frequency compounding.