Processing of neural activity in the human subthalamus in Parkinson´s disease: movement-related and pharmacological modulation

Author

Priori, A. ; Foffani, G. ; Bianchi, A.M. ; Baselli, G. ; Cerutti, S.

Author_Institution

Dept. of Biomed. Eng., Politecnico di Milano, Italy

fYear

2003

fDate

20-22 March 2003

Firstpage

482

Lastpage

484

Abstract

Electrodes for Deep Brain Stimulation offer the unique opportunity to record neural activity from the basal ganglia and to study their pathophysiology in living humans. Using time-frequency analysis techniques it is possible to evaluate the dependence of the spectral properties of human basal ganglia signals (1) on voluntary movement and (2) on drug administration. In this paper some of the results obtained by our group are reviewed and discussed.

Keywords

bioelectric potentials; biomedical electrodes; diseases; electroencephalography; medical signal processing; microelectrodes; neurophysiology; surgery; time-frequency analysis; EEG activity; Parkinson´s disease; basal ganglia signals; deep brain stimulation electrodes; digital signal processing; drug administration; local field potentials; subcutaneous pacemaker; subthalamic nucleus; surface EMG signal; surgical treatment; time-frequency analysis; voluntary movement; Basal ganglia; Brain stimulation; Drugs; Electrodes; Humans; Medical treatment; Parkinson´s disease; Satellite broadcasting; Surgery; Time frequency analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2003. Conference Proceedings. First International IEEE EMBS Conference on

Print_ISBN

0-7803-7579-3

Type

conf

DOI

10.1109/CNE.2003.1196867

Filename

1196867