Title :
Investigation of coding structure in DNA
Author :
Rosen, Gail L. ; Moore, Jeffrey D.
Author_Institution :
Center for Signal & Image Process., Georgia Inst. of Technol., GA, USA
Abstract :
We have all heard the term "cracking the genomic code", but is DNA a code in the information theoretic sense? The coined term "genetic code" maps nucleotide triplets (codons) to amino acids. However, this is in a computer coding sense because a codon instruction is performed to output an amino acid sequence. We examine methods to detect redundant coding structures in DNA. First, a finite field framework for a nucleotide symbolic sequence is presented; then approaches to finding the sequence structure associated with error correcting codes are examined. We compare a previously proposed parity-check vector search method to a novel subspace partitioning algorithm. The subspace partitioning algorithm is a general approach to finding any linear coding redundancy. Our method provides an easy way of visualizing coding potential in DNA sequences as shown from the test data.
Keywords :
DNA; Galois fields; error correction codes; genetics; DNA coding structure; Galois field; amino acid sequence; codon instruction; computer coding; error correcting codes; finite field framework; genetic code; genomic code; nucleotide symbolic sequence; nucleotide triplets; parity-check vector search method; redundant coding structure; subspace partitioning algorithm; Amino acids; Bioinformatics; Computer aided instruction; DNA; Error correction codes; Galois fields; Genetics; Genomics; Partitioning algorithms; Sequences;
Conference_Titel :
Acoustics, Speech, and Signal Processing, 2003. Proceedings. (ICASSP '03). 2003 IEEE International Conference on
Print_ISBN :
0-7803-7663-3
DOI :
10.1109/ICASSP.2003.1202370