Title :
A gradient model of the rabbit sinoatrial node
Author :
Cloherty, S.L. ; Dokos, S. ; Lovell, N.H.
Author_Institution :
Graduate Sch. of Biomedical Eng., New South Wales Univ., Sydney, NSW, Australia
Abstract :
We have formulated a gradient model of the rabbit sinoatrial node based on cell-specific ionic models of electrical activity from its central and peripheral regions. The gradient model exhibits a smooth transition in action potential characteristics such as maximum diastolic potential, overshoot potential, upstroke velocity, action potential duration and cycle length, and is suitable for developing higher dimensional models of the right atrium. Spontaneous pacemaker activity is simulated in a one-dimensional monodomain model of the sinoatrial node and adjoining atrial tissue.
Keywords :
bioelectric potentials; cellular biophysics; electrocardiography; physiological models; action potential characteristics; action potential duration; adjoining atrial tissue; cell-specific ionic models; cycle length; electrical activity; gradient model; maximum diastolic potential; one-dimensional monodomain model; overshoot potential; rabbit sinoatrial node; spontaneous pacemaker activity; upstroke velocity; Australia; Biomedical engineering; Biomembranes; Equations; Heart beat; Interpolation; Least squares methods; Pacemakers; Rabbits; Storage area networks;
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
Print_ISBN :
0-7803-7789-3
DOI :
10.1109/IEMBS.2003.1279487
