Finite element mathematical model of fluid and solute transport in hemofiltration membranes

Author

Conrad, S.A. ; Bidani, A.

Author_Institution

Dept. of Bioinformatics & Comput. Biol. & Medicine, Louisiana State Univ. Health Sci. Center, Shreveport, LA, USA

Volume

1

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

423

Abstract

Hemofiltration has been modeled with lumped compartment models that provide a good approximation of overall hemofilter performance. In order to model processes within the hemofilter fiber, a finite element model that includes momentum and mass transport was developed to simulate fluid and solute flux. In addition to convective and diffusive solute transport, the model incorporates non-Newtonian blood flow, viscosity effects of hematocrit and protein, and osmotic effects of protein. Simulations have suggested the role of protein osmotic effects as the singular basis for limitation of ultrafiltration, and have quantified the magnitude of back-nitration during dialysis and hemofiltration.

Keywords

biodiffusion; biomembrane transport; convection; filtration; finite element analysis; haemodynamics; haemorheology; non-Newtonian flow; non-Newtonian fluids; osmosis; proteins; viscosity; back-nitration; convective solute transport; diffusive solute transport; finite element mathematical model; fluid flux; fluid transport; hematocrit; hemofilter fiber; hemofilter performance; hemofiltration membranes; lumped compartment models; mass transport; nonNewtonian blood flow; osmotic effects; protein; solute flux; solute transport; ultrafiltration; Biomembranes; Blood flow; Equations; Finite element methods; Geometry; Mathematical model; Optical fiber polarization; Proteins; Solid modeling; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1279697

Filename

1279697