Title :
Inference of S-system models of genetic networks using a genetic local search
Author :
Kimura, Shuhei ; Hatakeyama, M. ; Konagaya, Akihiko
Author_Institution :
RIKEN Genomic Sci. Center, Yokohama, Japan
Abstract :
In this paper, we propose a new method for the inference of S-system models of large-scale genetic networks. This method employs a technique to decompose the genetic network inference problem into several subproblems, and then applies a genetic local search to each of the subproblems. A local search method utilizing the feature of the S-system model is used as one of the search operators in this genetic local search. Finally, the effectiveness of the proposed method is verified through a genetic network inference problem.
Keywords :
genetic algorithms; inference mechanisms; model-based reasoning; physiological models; search problems; S-system models; genetic local search; genetic network inference problem; genetic networks; search operators; Bioinformatics; Differential equations; Gene expression; Genetics; Genomics; Inference algorithms; Kinetic theory; Large-scale systems; Nonlinear equations; Search methods;
Conference_Titel :
Evolutionary Computation, 2003. CEC '03. The 2003 Congress on
Print_ISBN :
0-7803-7804-0
DOI :
10.1109/CEC.2003.1299635
