Title :
Non-Linear Steady-State Electrical Current Modeling for the Electropermeabilization of Biological Tissue
Author :
Breton, Marie ; Buret, Francois ; Krahenbuhl, Laurent ; Leguebe, Michael ; Mir, Lluis M. ; Perrussel, Ronan ; Poignard, Clair ; Scorretti, Riccardo ; Voyer, Damien
Author_Institution :
Team Vectorology & Anticancer Therapies, Inst. Gustave Roussy, Villejuif, France
Abstract :
We propose a non-linear steady-state model of irreversible electropermeabilization in a biological tissue. The non-linear problem is solved using a modified fixed point iteration. The unknown parameters are experimentally estimated from the observation of the necrosis on a potato tissue for different applied voltages. A variability study of the parameters involved in the model is performed.
Keywords :
bioelectric phenomena; biological effects of fields; biological tissues; iterative methods; biological tissue; irreversible electropermeabilization; modified fixed point iteration; nonlinear steady state electrical current modeling; potato tissue; Computational modeling; Conductivity; Electrodes; Mathematical model; Numerical models; Random variables; Uncertainty; Electropermeabilization (EP); non-linear conductivity;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2014.2351836
