Implantable probe systems for cortical neuroprostheses

Summary form only given. Next-generation neuroprostheses are likely to involve monitoring or stimulating selective regions of the brain to restore neurological function or treat disease. An enabling technology for these devices is a microscale implantable neural probe system that provides a reliable interface with the brain at the cellular level for long periods of time. We have developed a silicon-based probe technology that has proven to be effective for recording neural activity from neuronal populations for sustained time periods. This technology is currently being extended to include a combined chemical interface for drug delivery, advanced coatings for improved biocompatibility, and integrated electronics for wireless communication to the outside world.