Partial volume effect in quantitative magnetic resonance perfusion imaging

In dynamic-susceptibility contrast (DSC) magnetic resonance (MR) perfusion imaging, the cerebral blood flow (CBF) is estimated from the tissue residue function obtained through deconvolution of the contrast concentration functions. However, the reliability of CBF estimates obtained by deconvolution is sensitive to various distortions. Among the most prominent experimental limitations is the image spatial resolution, leading to partial volume effect (PVE), which arises when the size of the voxel exceeds the volume containing the arterial input signal. PVE results in distortion of the arterial input function (AIF), and directly leads to miscalculation of the CBF. This work demonstrates the degree of the CBF estimation bias that could develop as a result of PVE.