Multiphoton optical biopsy

Multiphoton microscopy is to a powerful imaging modality in the life sciences. The improved image contrast, greater imaging depths, and focus limited photodamage enable multiphoton microscopy to be especially useful for in vivo bioimaging applications. For multiphoton microscopy to be widely applicable in for in vivo biopsy applications, characterization of the tissues of interest must first be performed ex vivo. This presentation is an overview of the microscopic and spectroscopic characterization of the tissue types being pursued by my group. Both multiphoton images and spectroscopic information of a diverse range of normal, damaged, or diseased tissues will be presented and the implications of our results discussed.