Autofluorescence lifetime for identifying premalignant and normal oral tissues

Author

You, Chun ; Chen, Hsin-Ming ; Chiang, Chun-Pin ; Chen, Chin-Tin ; Wang, Chih-Yu

Author_Institution

Dept. of Biomed. Eng., I-Shou Univ., Taiwan

fYear

2004

fDate

14-17 Dec. 2004

Firstpage

105

Lastpage

106

Abstract

In this study, we evaluate the feasibility of using time-resolved autofluorescence spectroscopy for differentiating normal oral mucosa (NOM) from oral premalignant lesions including verrucous hyperplasia (VH), epithelial hyperplasia (EH), and epithelial dysplasia (ED). Time-resolved autofluorescence was measured at 633 nm under 410-nm excitation for 15 VH, 9 EH, 14 ED, and 38 NOM samples, and the two-component lifetimes for each measurement were calculated and a two-dimensional scatter plot was constructed. A Fisher´s discriminant analysis (FDA) were used to classify the 4 types of tissues. The result showed that 71% of EH and VH, 86% of ED, and 100% of NOM samples were correctly identified.

Keywords

biological tissues; biomedical measurement; fluorescence spectroscopy; time resolved spectroscopy; 633 nm; Fisher discriminant analysis; autofluorescence lifetime; epithelial dysplasia; epithelial hyperplasia; normal oral mucosa; normal oral tissues; premalignant oral tissues; time-resolved autofluorescence spectroscopy; two-component lifetimes; two-dimensional scatter plot; verrucous hyperplasia; Biomedical engineering; Biomedical measurements; Cancer; Dentistry; Fluorescence; Humans; Laser excitation; Lesions; Pulse measurements; Spectroscopy;

fLanguage

English

Publisher

ieee

Conference_Titel

Biophotonics, 2004. APBP 2004. The Second Asian and Pacific Rim Symposium on

Print_ISBN

0-7803-8676-0

Type

conf

DOI

10.1109/APBP.2004.1412301

Filename

1412301