DocumentCode :
430463
Title :
Application of differential phase detection for sensitivity improvement in surface plasmon resonance sensors
Author :
Ho, H.P. ; Wu, S.Y. ; Law, W.C. ; Lin, Chinlon
Author_Institution :
Dept. of Electron. Eng., Chinese Univ. of Hong Kong, China
fYear :
2004
fDate :
14-17 Dec. 2004
Firstpage :
221
Lastpage :
222
Abstract :
Surface plasmon resonance (SPR) is an effective tool for quantitative detection of binding reaction between biomolecules. Currently SPR sensors are mainly based on measuring the angular shift associated with biomolecular adhesion. In fact it has been shown that the phase jump across the SPR dip is very steep, and consequently better sensitivity may be achieved by measuring the optical phase. In this presentation, we report interferometric techniques we have developed in our laboratory for achieving SPR phase detection. We also demonstrate that the incorporation of differential phase detection can further improve the performance of SPR biosensors. Currently the experimental sensitivity of our differential phase setup is 5.48×10-8 refractive index unit (RIU), which is three times better than that reported from conventional angular systems.
Keywords :
Mach-Zehnder interferometers; biosensors; light interferometry; molecular biophysics; optical variables measurement; phase measurement; refractive index; surface plasmon resonance; Mach-Zehnder interferometers; SPR biosensors; SPR phase detection; biomolecular binding reaction; differential phase detection; differential phase setup; interferometric technique; optical phase measurement; quantitative detection; refractive index unit; sensitivity improvement; surface plasmon resonance sensors; Adhesives; Biomedical optical imaging; Biosensors; Current measurement; Molecular biophysics; Optical interferometry; Phase detection; Phase measurement; Plasmons; Resonance;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biophotonics, 2004. APBP 2004. The Second Asian and Pacific Rim Symposium on
Print_ISBN :
0-7803-8676-0
Type :
conf
DOI :
10.1109/APBP.2004.1412361
Filename :
1412361
Link To Document :
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